Feline Infectious Peritonitis: Neurological and Ocular FIP by Dr. Niels Pedersen


Neurological FIP: Can It Be Cured?

This article was published by Dr. Niels Pedersen. Published with permission.

Treatment of neurological and/or ocular FIP

"The only effective treatment for neurological and/or ocular FIP is an antiviral drug such as GS-441524. The minimum dosage regimen for this form of FIP should be 5 mg/kg, SC, q24 h for at least 12 weeks. We have found this treatment to cause a rapid reversal of clinical signs within days, a return to near normal within two weeks, and a return to full normalcy within 8 weeks or so. The best gauges of normalcy are weight gain, growth if retarded by the disease, and the ability to once again jump to previous heights without hesitation.Although GS-441524 is highly effective in reversing abnormal clinical signs in cats with neurological disease, it is not always curative. Relapses of disease following cessation of treatment have occurred within days to several weeks after stopping treatment and the relapse rate appears to be much higher than for cats suffering other forms of FIP.We have treated only six cats with neurological disease (four also with ocular disease). One cat relapsed with neurological disease after completing treatment at a dosage of 2 mg/kg, SC, q24h and was cured at a dosage of 4 mg/kg, SC, q24 h, while a second cat was treated twice at 2 mg/kg and relapsed each time. A third and fourth cat was treated at a dosage of 5 mg/kg and cured, while a fifth cat relapsed after two identical treatments at the same dosage. A sixth cat relapsed at 5 and 8 mg/kg and is now being treated at a dosage of 10 mg/kg.Cats that cannot be cured of FIP can be kept in a state of normalcy with indefinite treatment, but this can be a costly endeavor and with unknown long term side effects and the spectrum of drug resistance". View the pdf by clicking “article” above.